INSTITUTE OF PHYSIOLOGY

Prof. Dr. Ralf Mohrmann

Professor/-in

Prof. Dr.ret.nat. Ralf Mohrmann

Institut für Physiologie (IPHY)
Leipziger Str. 44 , 39120 Magdeburg, H13/105
Vita
since 2018

Full Professorship (W2) „Neurophysiology and celular Imaging“, Otto-von-Guericke-University Magdeburg (Germany)

2015-2017

Workgroup leader, Saarland-University (Germany) 

2013-2020

Research project leader (together with Prof. Dr. D. Bruns) in CRC 1027 „Physical Modeling of non-equilibrium processes in biological system“  

2009-2016

Junior-Professorship (ZHMB Junior Group Physiology), Saarland-University (Germany)

2006-2009

Postdoc at the Dept.  Membrane Biophysics (Director: Prof. Dr. Erwin Neher), workgroup of PD Dr. Jakob Sørensen, MPI f. Biophysical Chemistry, Göttingen (Germany)

2001-2005

Postdoc in the lab of Prof. Dr. Kendal Broadie, Vanderbilt University, Nashville (U.S.A.)

1997-2001

Dissertation at the Dept. Cell Physiology (Supervisor: PD. Dr. Kurt Gottmann), Faculty of Biology, Ruhr-University Bochum (Germany)

Titel: “Mechanisms and Regulation of Synaptogenesis in cultivated neocortical Neurons.“

1997

Diploma thesis, Dept. Cell Physiology (Prof. Dr. Hanns Hatt), Faculty of Biology, Ruhr-University Bochum (Germany)

1992-1996

Study of Biochemistry (Diploma) at Ruhr-University Bochum (Germany)

Publications

  

2021

 

Harb A, Vogel N, Shaib A, Becherer U, Bruns D, Mohrmann R.

Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons

Front Mol Neurosci. 2021 Aug 23;14:728498. doi: 10.3389/fnmol.2021.728498. eCollection 2021.

 zur Publikation

Houy S, Martins JS, Mohrmann R, Sørensen JB.
Measurements of Exocytosis by Capacitance Recordings and Calcium Uncaging in Mouse Adrenal Chromaffin Cells
Methods Mol Biol;2233:233-251. doi: 10.1007/978-1-0716-1044-2_16. PMID: 33222139 (2021).

 zur Publikation

 

2020

 

Dhara M, Mantero Martinez M, Makke M, Schwarz Y, Mohrmann R, Bruns D.
Synergistic actions of v-SNARE transmembrane domains and membrane-curvature modifying lipids in neurotransmitter release
Elife. May 11;9:e55152. doi: 10.7554/eLife.55152

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2019

 

Shaaban A, Dhara M, Frisch W, Harb A, Shaib AH, Becherer U, Bruns D, Mohrmann R.

The SNAP-25 linker supports fusion intermediates by local lipid interactions.

Elife. 2019 Mar 18;8:e41720. doi: 10.7554/eLife.41720.

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2018

Dhara M, Mohrmann R, Bruns D.

v-SNARE function in chromaffin cells.

Pflugers Arch. 2018 Jan;470(1):169-180. doi: 10.1007/s00424-017-2066-z.

zur Publikation

Makke M, Mantero Martinez M, Gaya S, Schwarz Y, Frisch W, Silva-Bermudez L, Jung M, Mohrmann R, Dhara M, Bruns D.

A mechanism for exocytotic arrest by the Complexin C-terminus.

Elife. 2018 Jul 25;7:e38981. doi: 10.7554/eLife.38981.

zur Publikation

Shaib AH, Staudt A, Harb A, Klose M, Shaaban A, Schirra C, Mohrmann R, Rettig J, Becherer U.

Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons

Front Cell Neurosci. 2018 Sep 11;12:304. doi: 10.3389/fncel.2018.00304.

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2016

 

Dhara M, Yarzagaray A, Makke M, Schindeldecker B, Schwarz Y, Shaaban A, Sharma S, Böckmann RA, Lindau M, Mohrmann R, Bruns D.

v-SNARE transmembrane domains function as catalysts for vesicle fusion.

Elife. 2016 Jun 25;5:e17571. doi: 10.7554/eLife.17571.

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2015

 

Mohrmann R, Dhara M, Bruns D.

Complexins: small but capable.

Cell Mol Life Sci. 2015 Nov;72(22):4221-35. doi: 10.1007/s00018-015-1998-8. Epub 2015 Aug 6.

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2014

 

Dhara M, Yarzagaray A, Schwarz Y, Dutta S, Grabner C, Moghadam PK, Bost A, Schirra C, Rettig J, Reim K, Brose N, Mohrmann R, Bruns D.

Complexin synchronizes primed vesicle exocytosis and regulates fusion pore dynamics.

J Cell Biol. 2014 Mar 31;204(7):1123-40. doi: 10.1083/jcb.201311085.

zur Publikation

Weber JP, Toft-Bertelsen TL, Mohrmann R, Delgado-Martinez I, Sørensen JB.

Synaptotagmin-7 is an asynchronous calcium sensor for synaptic transmission in neurons expressing SNAP-23.

PLoS One. 2014 Nov 25;9(11):e114033. doi: 10.1371/journal.pone.0114033

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2013

 

Borisovska M, Schwarz YN, Dhara M, Yarzagaray A, Hugo S, Narzi D, Siu SW, Kesavan J, Mohrmann R, Böckmann RA, Bruns D.

Membrane-proximal tryptophans of synaptobrevin II stabilize priming of secretory vesicles.

J Neurosci. 2012 Nov 7;32(45):15983-97. doi: 10.1523/JNEUROSCI.6282-11.2012.

zur Publikation

Mohrmann R, de Wit H, Connell E, Pinheiro PS, Leese C, Bruns D, Davletov B, Verhage M, Sørensen JB.

Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.

J Neurosci. 2013 Sep 4;33(36):14417-30. doi: 10.1523/JNEUROSCI.1236-13.2013.

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2012

Mohrmann R, Sørensen JB. 

SNARE requirements en route to exocytosis: from many to few.

J Mol Neurosci. 2012 Oct;48(2):387-94. doi: 10.1007/s12031-012-9744-2.

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2010

 

Mohrmann R, de Wit H, Verhage M, Neher E, Sørensen JB.

Fast vesicle fusion in living cells requires at least three SNARE complexes.

Science. 2010 Oct 22;330(6003):502-5. doi: 10.1126/science.1193134. Epub 2010 Sep 16.

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